来自ASCO年会的最新进展,对于乳腺癌患者和晚期肾癌(肾细胞癌)患者而言,是重要且有用的信息,值得他们在与肿瘤专科医生讨论时加以考虑。
美国临床肿瘤学会(ASCO)年会于2018年6月1日至5日在美国伊利诺伊州芝加哥的麦考密克会展中心举行。与会者与该领域的专家共同探讨了癌症治疗领域的诸多最新进展,涵盖从诊断、检测到研究及治疗的各个方面。
This year’s theme is expanding the reach of precision medicine. Precision medicine in oncology means selecting appropriate and optimal therapies suitable for the patient based on the patient's genetic profile and/or the tumour characteristics. The TAILORx study was discussed at ASCO 2018 regarding breast cancer treatment. Investigators found that the gene expression assay called Oncotype Dx for breast cancer could help ER-positive, HER2-negative, node-negative breast cancer patients. Patients with a low RS score have a low risk of recurrence and may avoid adjuvant chemotherapy. In the study, those with an RS of 11 to 25, endocrine therapy alone was noninferior to endocrine therapy plus chemotherapy. However, amongst women who are 50 years or younger, they may still derive benefit from chemotherapy if the RS score is 16-25. This should be discussed further with the patient’s treating doctor.
会议上还公布了另一项关于晚期肾癌(肾细胞癌)的重要研究(CARMENA试验)。多年来,晚期肾癌患者的标准治疗方案一直是先通过手术切除肾脏,随后进行全身治疗。 舒尼替尼(Sutent)是治疗晚期肾癌的重要药物,这是一种口服靶向治疗药物。研究评估了在靶向治疗时代,针对中危和高危肾癌患者进行减瘤性肾切除术(肾脏手术)的必要性。研究人员发现,单用舒尼替尼的疗效不逊于先行肾切除术再联合舒尼替尼治疗。这对晚期肾癌患者在与肿瘤专科医生讨论治疗方案时具有重要参考价值。
“专业知识意味着更好的癌症护理”
作者:
彼得·安医生
医学学士(新加坡)
医学硕士(内科)
英国皇家内科医学院会员
新加坡医学会院士(肿瘤内科)